KMID : 1141520170320020241
|
|
Endocrinology and Metabolism 2017 Volume.32 No. 2 p.241 ~ p.247
|
|
Effects of Vildagliptin or Pioglitazone on Glycemic Variability and Oxidative Stress in Patients with Type 2 Diabetes Inadequately Controlled with Metformin Monotherapy: A 16-Week, Randomised, Open Label, Pilot Study
|
|
Kim Nam-Hoon
Kim Dong-Lim Kim Kyeong-Jin Kim Nan-Hee Choi Kyung-Mook Baik Sei-Hyun Kim Sin-Gon
|
|
Abstract
|
|
|
Background: Glycemic variability is associated with the development of diabetic complications through the activation of oxidative stress. This study aimed to evaluate the effects of a dipeptidyl peptidase 4 inhibitor, vildagliptin, or a thiazolidinedione, pioglitazone, on glycemic variability and oxidative stress in patients with type 2 diabetes.
Methods: In this open label, randomised, active-controlled, pilot trial, individuals who were inadequately controlled with metformin monotherapy were assigned to either vildagliptin (50 mg twice daily, n=17) or pioglitazone (15 mg once daily, n=14) treatment groups for 16 weeks. Glycemic variability was assessed by calculating the mean amplitude of glycemic excursions (MAGE), which was obtained from continuous glucose monitoring. Urinary 8-iso prostaglandin F2¥á, serum oxidised low density lipoprotein, and high-sensitivity C-reactive protein were used as markers of oxidative stress or inflammation.
Results: Both vildagliptin and pioglitazone significantly reduced glycated hemoglobin and mean plasma glucose levels during the 16-week treatment. Vildagliptin also significantly reduced the MAGE (from 93.8¡¾38.0 to 70.8¡¾19.2 mg/dL, P=0.046), and mean standard deviation of 24 hours glucose (from 38¡¾17.3 to 27.7¡¾6.9, P=0.026); however, pioglitazone did not, although the magnitude of decline was similar in both groups. Markers of oxidative stress or inflammation including urinary 8-iso prostaglandin F2¥á did not change after treatment in both groups.
Conclusion: In this 16-week treatment trial, vildagliptin, but not pioglitazone, reduced glycemic variability in individuals with type 2 diabetes who was inadequately controlled with metformin monotherapy, although a reduction of oxidative stress markers was not observed.
|
|
KEYWORD
|
|
Glycemic variability, Dipeptidyl-peptidase IV inhibitors, Thiazolidinediones, Diabetes mellitus, type 2
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|